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(Senior) Vice President, Therapeutic Discovery ID-12329

April 22, 2025

The Opportunity

insitro is pioneering a new approach to drug discovery and development, enabled by the use of advanced machine learning to interrogate large amounts of cellular, molecular and clinical data to increase the probability of clinical success. The insitro platforms are generating new therapeutic discovery programs in neurological, metabolic and proliferative disease across a range of fit-for-purpose modalities (small molecule, oligonucleotides, biologics) with both internal capabilities and partners. We are looking for a data-driven Therapeutic Discovery leader, who will guide our molecular strategies and preclinical drug discovery, and ensure that we optimally use our machine learning capabilities both to increase the success of our preclinical programs and to accelerate them.

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Your primary duties will be:

Oversee multi-modality therapeutic discovery:
- Build and lead a team of drug discovery professionals in areas including: medicinal chemistry; DNA-encoded chemical library design, synthesis and screening; complex biologics; oligonucleotides; analytical sciences; PKDM; protein sciences and structural biology
- Partner with Therapeutic Areas, Technical Operations, Preclinical & Clinical Development to develop indication strategies
- Support drug discovery project teams to rapidly advance internal therapeutic leads and backups into IND-enabling studies and FIH trials
- Engage operationally and strategically with Pharma, Biotech and provider partners to prosecute collaborative drug-discovery programs
Guide strategy on molecular design and technology:
- Collaborate with cross-functional teams, including machine learning scientists, bioinformaticians, and statisticians, to develop advanced capabilities that can increasingly replace laboratory experimentation with modeling and simulation
- Identify and access/internalize relevant innovative technologies that can meaningfully accelerate drug discovery and translational success
- Foster collaborations with external partners, key opinion leaders, and academic institutions to enhance our scientific knowledge
Collaborate on company strategy and communications:
- Provide scientific leadership and strategic input across all stages of drug development, from target identification to post-marketing activities
- Work with other company leaders to guide our corporate strategy, bringing in perspectives on therapeutic modalities, tractability of drug development and manufacturing strategies
- Partner with Corporate Development and Strategy on new partnership initiatives and in-licensing/out-licensing activities
Broader communication:
- Effectively communicate our clinical strategy and progress to stakeholders, including the board of directors, investors, and regulatory agencies

About You

Scientific experience

Graduate degree in a relevant molecular discipline (organic, oligonucleotide or peptide chemistry; protein engineering)
15+ years of experience in therapeutic discovery within the pharmaceutical or biotechnology industry, with a track record of successful early development candidates
Leading role in the design and execution of multiple drug discovery programs ideally across one therapeutic area relevant to insitro (neuroscience, metabolic disease)
Experience with multiple therapeutic modalities with a strong foundation in all aspects of synthetics drug discovery
Interest in and exposure to cutting-edge computational and data science methods
Appreciation for human genetics and its use in target identification or validation

Leadership/personality traits

Data-driven, quantitative mindset, and a track record of collecting and utilizing data in clinical development
Track record in building and leading a high-performance team, with extensive experience at the executive level
Ability to interact effectively across disciplinary boundaries, including with people from very diverse backgrounds
A can-do attitude consistent with a small startup environment, including ability to move quickly, work hard, and do what it takes to be successful
Excellent communication skills, including the ability to convey complex medical and scientific concepts to diverse audiences
Demonstrated strategic thinking and a visionary approach to medical leadership in the context of AI-driven drug development

Nice to have

Significant strategic role in at least one NME that has obtained full regulatory approval (BLA or NDA)
Experience in company building and the establishment of significant drug discovery capabilities

Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $300,000.00 - $360,000.00. To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

401(k) plan with employer matching for contributions
Excellent medical, dental, and vision coverage as well as mental health and well-being support
Open, flexible vacation policy
Paid parental leave of at least 16 weeks to support parents who give birth, and 10 weeks for a new parent (inclusive of birth, adoption, fostering, etc)
Quarterly budget for books and online courses for self-development
Support to attend professional conferences that are meaningful to your career growth and role's responsibilities
New hire stipend for home office setup
Monthly cell phone & internet stipend
Access to free onsite baristas and cafe with daily lunch and breakfast for employees who are either onsite or hybrid
Access to free onsite fitness center for employees who are either onsite or hybrid
Access to a free commuter bus and ferry network that provides transport to and from our South San Francisco HQ from locations all around the Bay Area

insitro is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work to bring together diverse teams-grounded in different expertise and life experiences-and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. You can expect equitable treatment, respect, and fairness throughout the interview process.

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Common Interview Questions And Answers

1. HOW DO YOU PLAN YOUR DAY?

This is what this question poses: When do you focus and start working seriously? What are the hours you work optimally? Are you a night owl? A morning bird? Remote teams can be made up of people working on different shifts and around the world, so you won't necessarily be stuck in the 9-5 schedule if it's not for you...

2. HOW DO YOU USE THE DIFFERENT COMMUNICATION TOOLS IN DIFFERENT SITUATIONS?

When you're working on a remote team, there's no way to chat in the hallway between meetings or catch up on the latest project during an office carpool. Therefore, virtual communication will be absolutely essential to get your work done...

3. WHAT IS "WORKING REMOTE" REALLY FOR YOU?

Many people want to work remotely because of the flexibility it allows. You can work anywhere and at any time of the day...

4. WHAT DO YOU NEED IN YOUR PHYSICAL WORKSPACE TO SUCCEED IN YOUR WORK?

With this question, companies are looking to see what equipment they may need to provide you with and to verify how aware you are of what remote working could mean for you physically and logistically...

5. HOW DO YOU PROCESS INFORMATION?

Several years ago, I was working in a team to plan a big event. My supervisor made us all work as a team before the big day. One of our activities has been to find out how each of us processes information...

6. HOW DO YOU MANAGE THE CALENDAR AND THE PROGRAM? WHICH APPLICATIONS / SYSTEM DO YOU USE?

Or you may receive even more specific questions, such as: What's on your calendar? Do you plan blocks of time to do certain types of work? Do you have an open calendar that everyone can see?...

7. HOW DO YOU ORGANIZE FILES, LINKS, AND TABS ON YOUR COMPUTER?

Just like your schedule, how you track files and other information is very important. After all, everything is digital!...

8. HOW TO PRIORITIZE WORK?

The day I watched Marie Forleo's film separating the important from the urgent, my life changed. Not all remote jobs start fast, but most of them are...

9. HOW DO YOU PREPARE FOR A MEETING AND PREPARE A MEETING? WHAT DO YOU SEE HAPPENING DURING THE MEETING?

Just as communication is essential when working remotely, so is organization. Because you won't have those opportunities in the elevator or a casual conversation in the lunchroom, you should take advantage of the little time you have in a video or phone conference...

10. HOW DO YOU USE TECHNOLOGY ON A DAILY BASIS, IN YOUR WORK AND FOR YOUR PLEASURE?

This is a great question because it shows your comfort level with technology, which is very important for a remote worker because you will be working with technology over time...

DISCLAIMER

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Common Interview Questions And Answers

1. HOW DO YOU PLAN YOUR DAY?

2. HOW DO YOU USE THE DIFFERENT COMMUNICATION TOOLS IN DIFFERENT SITUATIONS?

3. WHAT IS "WORKING REMOTE" REALLY FOR YOU?

4. WHAT DO YOU NEED IN YOUR PHYSICAL WORKSPACE TO SUCCEED IN YOUR WORK?

5. HOW DO YOU PROCESS INFORMATION?

6. HOW DO YOU MANAGE THE CALENDAR AND THE PROGRAM? WHICH APPLICATIONS / SYSTEM DO YOU USE?

7. HOW DO YOU ORGANIZE FILES, LINKS, AND TABS ON YOUR COMPUTER?

8. HOW TO PRIORITIZE WORK?

9. HOW DO YOU PREPARE FOR A MEETING AND PREPARE A MEETING? WHAT DO YOU SEE HAPPENING DURING THE MEETING?

10. HOW DO YOU USE TECHNOLOGY ON A DAILY BASIS, IN YOUR WORK AND FOR YOUR PLEASURE?